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However, a cut point score indicative of clinically relevant body image concerns has not been establi... Methamphetamine (MA) is a highly addictive stimulant with recent upward trends in prevalence and associated public health problems. The secondary focus was to determine if any demographic/drug use variables or comorbid psychiatric diagnoses (e.g. Boxplot analysis of the bacterial genera in oral samples per exposure group. Dr. Maria De La Garza Bravo, MD is a board certified pathologist in Houston, Texas. The anterior cingulate cortex (ACC) is hypothesized to be involved in decision making and emotion regulation. Our study is the first to examine if the safe and low-interaction AChEi rivastigmine (riv) alters the subjective... Background and Objectives Facebook gives people the power to share … Pharmacology, Biochemistry, and Behavior . Subjective effects were assessed with visual analog s... Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Richard lived in 1935, at address , Texas. She also is interested in the treatment of anxiety in patients with dementia, the delivery of mental health services in primary care and in the community, and the integration of religion and spirituality into CBT. American Journal on Addiction. In this pilot study, we sought to determine if ECs or tobacco smoking alter the oral... Correlations between the top 10 most abundant genera per sample type and the CO levels based on linear regression. Contact her at deborah.little@bcm.edu. Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: A pilot study, Predictive value of distress tolerance measures in successful weight loss, An Examination of the Relationship Between Insomnia and Tinnitus: A Review and Recommendations, Incidence of Antiemetic‐Induced Akathisia in Patients at a Comprehensive Cancer Center, Breath holding endurance: Stability over time and relationship with self-assessed persistence, The limited impact that cocaine use patterns have on neurocognitive functioning in individuals with cocaine use disorder, Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes, 040 Self-Reported Sexual Problems are Higher in Breast Cancer vs. Concurrent administration of dopamine and serotonin reuptake inhibitors reduces cocaine self-administration in monkeys. Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: a pilot study Christopher J. Stewart1,2, Thomas A. Auchtung1, Nadim J. Ajami1, Kenia Velasquez3,4, Daniel P. Smith1, Richard De La Garza II3,4,5, Ramiro Salas3,4,5 and Joseph F. Petrosino1 1 Alkek Center for Metagenomics and Microbiome Research, Department of Molecular … In particular, acetylcholinesterase inhibitors, like huperzine A, may be effective as treatments for cocaine use disorder. We hypothesize that insomnia is a highly prevalent symptom and diagnostic category accompanying tinnitus. She is also studying treatment outcome of a cognitive-behavioral group intervention for PTSD-related sleep disturbance. Only verified researchers can join ResearchGate and send messages to other members. This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine. Christopher D Verrico 1 , Colin N Haile, Thomas F Newton, Thomas R Kosten, Richard De La Garza 2nd Affiliation 1 Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine , One Baylor Plaza, Houston, TX 77030-3411 , USA verrico@bcm.edu. Non-treatment-seeking volunteers (n=66) with cocaine use disorders received a single bolus infusion of saline and cocaine (40 mg, intravenous) in a randomized order. He also does general pediatric psychopharmacology for affective and other disorders. Con, control; EC, electronic cigarette user, TS, tobacco smoker. Objective Contact her at mstanley@bcm.edu. Corresponding Author. Terri Fletcher, Ph.D., Assistant Professor, conducts health services research using to improve access to evidence-based treatments for Veterans with anxiety disorders, posttraumatic stress disorder, and obsessive-compulsive disorder. Body image is a vital and complex issue in cancer patients, but not well recognized. Dr. De La Garza is interested in cancer prevention as it relates to smoking cessation research, including testing of electronic cigarettes. Consonant with this, clinical trials assessing modafinil and selective serotonin reuptake inhibitors alone show some efficacy as potential pharmacotherapies for cocaine dependence. Alan Swann, M.D., Professor, does clinical and translational research focusing on behavior, neurophysiology and biomarkers related to action control and behavioral sensitization. We conducted the present study to better understand how disulfiram alters the reinforcing effects of cocaine in cocaine users. He is currently studying outcomes of suicide-specific interventions and exploring predictors and mediators of changes in suicidality over the course of treatment. Her research interests focus on the design and application of contingency management (CM) techniques in reinforcing desired behaviors. Due to our privacy policy, only current members can send messages to people on ResearchGate. Contact her at: natalie.hundt@va.gov. So far, about 25 percent of the patients have been enrolled. Richard passed away on month day 2016, at age 80 at death place , Texas. Participants (N=24) included treatment-seeking individuals with concurrent cocaine and tobacco-use disorder (cigarette smokers). Tracey L. Smith, Ph.D., Associate Professor, conducts psychotherapy research: development and implementation of new treatments; psychotherapy training; psychotherapy processes and outcomes. Lea Steele, Ph.D., Professor, epidemiology and pathobiology of complex neuroimmune disorders. Contact him at joldham@bcm.edu. He is interested in looking at psychopharmacology of medicines, their use in pregnancy and lactation, and use of psychotropics in geriatrics. Contact her at terrif@bcm.edu. Although there are no Food and Drug Administration (FDA)-approved medications for methamphetamine dependence, preclinical and clinical studies suggest that methamphetamine users may benefit from treatments that enhance cholinergic neurotransmission. Contact him at rg12@bcm.edu. Contact her at laura.marsh2@va.gov. Contact him at asgharal@bcm.edu. Genera ordered based on P value by reverse numerical order. No genera were found to be significantly different by exposure in either (A) Buccal swab or (B) Saliva. 2014 October 30; 219 (2): 367-71. Contact him at verrico@bcm.edu. This study aimed to evaluate whether functional variants in the ankyrin repeat and kinase domain-containing 1 gene (ANKK1) and/or the dopamine receptor D2 gene (DRD2) modulate the subjective effects (reward or non-reward response to a stimulus) produced by cocaine administration. Objective: There is currently a gap in on-site drug of abuse monitoring. View Richard De La Garza’s professional profile on Relationship Science, the … Remote physiological monitoring of acute cocaine exposure, Substance-Related and Addictive Disorders, A variant in ANKK1 modulates acute subjective effects of cocaine: A preliminary study, Safety and efficacy of varenicline to reduce positive subjective effects produced by methamphetamine in methamphetamine-dependent volunteers, Assessment of Safety, Cardiovascular and Subjective Effects After Intravenous Cocaine and Lofexidine. She uses cognitive behavioral therapy to facilitate treatment improvements and outcomes. Cocaine-dependent participants (N = 47) were administered 40 mg of co... Methamphetamine use is increasing in the US. Objective: The second is a joint project with Dr. Nabil Guirguis through the HHS system. Cholinergic transmission is altered by drugs of abuse and contributes to psychostimulant reinforcement. Access our COVID-19 Response homepage, with more information and resources during the COVID-19 pandemic, including what to do if you’re experiencing symptoms. Neurocognitive effects following an overnight call shift on faculty anesthesiologists, The Influence of Smoking Cigarettes on the High and Desire for Cocaine among Active Cocaine Users, The Impact of Disulfiram Treatment on the Reinforcing Effects of Cocaine: A Randomized Clinical Trial, D-Cycloserine administration does not affect neurocognition in concurrent cocaine- and nicotine-dependent volunteers, Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users, The relationship between lifetime stress and addiction severity in cocaine-dependent participants, Rivastigmine Reduces “Likely to Use Methamphetamine” in Methamphetamine-Dependent Volunteers, Department of Behavioral Medicine and Psychiatry, Department of Psychiatry and Biobehavioural Sciences, Department of Biomaterials and Biomimetics, Virginia Tech Carilion School of Medicine and Research Institute, Department of Psychiatry and Behavioral Sciences. Contact him at nielsen@bcm.edu. PurposeAdequate adjustment to bodily changes during various phases of cancer treatment is important to patients’ emotional well-being. Laura Marsh, M.D., Professor, her research interest is in the neuropsychiatric aspects of Parkinson's disease, with a focus on improving characterization of clinical phenomenology and developing methods and approaches to improve the recognition and treatment of psychiatric disturbances in patients with Parkinson's disease and related movement disorders. Analysis of bacterial profiles based on sample type. You can help our author matching system! She is currently licensed to practice medicine in Texas, North Carolina, and Oregon. Can cancer‐related cognitive impairment be considered in isolation from other cancer‐related symptoms? The modulatory influence of dopamine in m... Current cocaine treatments may be enhanced with a better understanding of the underlying mechanisms that contribute to the onset and maintenance of the disease, such as life stress and impulsivity. At present, Dr. De La Garza is Professor with tenure in the Menninger Department of Psychiatry and Behavioral Sciences at the Baylor College of Medicine. John Oldham, M.D., Professor Emeritus, personality disorders particularly borderline personality disorder and treatment outcome with inpatient care. The current study compared two discounting tasks: money now versus money later (M‐M) and metha... Background Ali Abbas Asghar-Ali, M.D., Associate Professor, is the Geriatric Psychiatry Fellowship Director who is a co-investigator with Dr. Sanjay Mathews on trials involving ketamine and ECT. In the present study, we tested the hypothesis that the potent and selective dopamine-β-hydroxylase (DβH) inhibitor nepicastat would have minimal effects on cardiovascular and pharmacokinetic parameters associated with cocaine administration and would reduce the positive subjective effects produced by cocaine. Evaluation of guanfacine administration on cognition in volunteers with cannabis-use disorder, Comparison of perceptions of HIV risk and risky sexual practices among heterosexual cocaine- dependent individuals, Cocaine-induced subjective effects differ between African Americans and Caucasians, Evaluation of lisdexamfetamine alone and lisdexamfetamine+modafinil for cocaine use disorder, Varenicline improves information processing speed and verbal memory in methamphetamine-dependent participants, Choosing money over drugs: The underpinnings of rational choice in cocaine addicts, Next Generation Programmable Bio-Nano-Chip System for On-Site Quantitative Drug Detection in Oral Fluids, Withdrawal Symptoms and Nicotine Dependence Severity Predict Virtual Reality Craving in Cigarette-Deprived Smokers, A comparison of impulsivity, depressive symptoms, lifetime stress and sensation seeking in healthy controls versus participants with cocaine or methamphetamine use disorders, Characterizing white matter changes in cigarette smokers via diffusion tensor imaging, Perceptions about e-cigarette safety may lead to e-smoking during pregnancy, Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users, Treatment with Modafinil and Escitalopram, Alone and in Combination, on Cocaine-Induced Effects: a Randomized, Double Blind, Placebo-Controlled Human Laboratory Study, Subjective effects produced by cocaine are in association with genetic variants of DAT1, Association between α-1 adrenergic receptor (ADRA1A) genotype and subjective cocaine effect in cocaine-dependent individuals, Virtual reality-induced craving for cigarettes among abstinent smokers, Genetic variants of the dopaminergic system associated with subjective responses to cocaine, Fatty acid amide hydrolase gene variant influences acute responses to cocaine, Ketamine for treatment-resistant depression: Subjective effects and impact on plasma brain-derived neurotrophic factor, Programmable Bio-Nano-Chips for the quantitation of drugs of abuse in oral fluids, State versus trait: Evaluating the stability of neurocognitive functioning over time in cocaine-dependent participants, A pilot study examining the efficacy of virtual-reality based relapse prevention among alcohol-dependent veterans with traumatic brain injury, Short-term, low-dose varenicline administration enhances information processing speed in methamphetamine-dependent users, The relationship between sleep and drug use characteristics in participants with cocaine or methamphetamine use disorders. Most of her studies involve the use of cognitive behavior therapy (CBT) for older people with anxiety and/or depression. The gut microbiota has recently gained attention as a possible modulator of brain activity. Contact her at lilian.dindo@bcm.edu. Ramiro Salas, Ph.D., Associate Professor, uses functional brain imaging to study the neuronal circuits that are involved in the processing of reward and disappointment, and how these circuits are changed in addiction, depression and other conditions. The condition is often missed, and patients suffer for a long time until diagnosed and managed properly. Methods: Clinical trials indicate that disulfiram (250 mg/d) reduces cocaine use, though one study found that treatment with lower doses of disulfiram (62.5 and 125 mg/d) increased cocaine use. Contact her at toih@bcm.edu. Drug demand, as assessed by hypothetical purchasing tasks, has been useful in addictions research and may help our understanding of the factors influencing MA use. He conducts research in clinical trials for medications and behavioral therapies for addiction to cocaine, methamphetamine, and opiates and for PTSD. This study was a within-participant, double-blind, placebo-controlled inpatient human laboratory evaluation of 65 nontreatment-seeking, cocaine-dependent [Diagnostic and Statis... Background: The aim of this study was to identify gene variants of DAT1 (SLC6A3) that modulate subjective responses to acute cocaine exposure. If a data field below is blank, it will not be used in the search function. ©1998-2020 Baylor College of Medicine® | One Baylor Plaza, Houston, Texas 77030 | (713)798-4951Have an edit or suggestion for this page? His research interests include pharmacogenetics and clinical trials of medications to treat addictive disorders. Richard De La Garza II is the author of Cocaine and Methamphetamine Dependence (3.33 avg rating, 3 ratings, 1 review, published 2011) Contact him at acswann@bcm.edu. Richard De La Garza is Professor, Pharmacology & Chemical Biology at Baylor College of Medicine. Participants self-reported subjective effects... Delay discounting describes how a reward loses value as a function of increasing delay to its receipt and has been reliably associated with a variety of vulnerable populations including those with substance use disorders (SUDs). View the profiles of professionals named "Richard De La Garza" on LinkedIn. Sanjay Mathew, M.D., Professor, does clinical and translational research that focuses on biomarkers and developing new drug therapies for refractory mood disorders and PTSD. About. Lilian Dindo, Ph.D., Assistant Professor, is focused on developing pragmatic and innovative ways to improve the mental health and functioning of patients suffering from comorbid psychiatric and medical conditions. She also uses neuroimaging, neurophysiology, genetics, metabolomics and neurocognitive testing to elucidate the phenotypic differences between individuals with illness, individuals at high risk, and healthy individuals, and maintains a clinical database for analyses of clinical outcomes and determinants of mental illness severity. All rights reserved. However, chronic cocaine users (CCUs) (C) Boxplot of most significant bacterial genera. INTRODUCTION: Illicit substance-use is a substantial public health concern, contributing over $150 billion in costs annually to Americans. Recent studies have demonstrated that different models for assessing discounting may result in disparate conclusions. Find out why.Get to Know Houston. Contact her at karin.thompson@va.gov. Incidence and characteristics of depression in cancer patients with chronic hepatitis C infection. Participants with a cocaine or meth use disorder completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepin... Abstract Cocaine exposure results in predictable cardiovascular changes. We examined whether a functional variant of the ADRA1A gene moderated cocaine-induced subjective effects in a group of cocaine-dependent individuals. Because e-cigarettes lack many of the substances found in regular tobacco, they are often perceived as a safer smoking alternative, especially in high-risk situations such as pregnancy. He also studies the epigenetics of addictive drugs, cocaine associated decreases in brain white matter integrity, TBI, and maternal behavior. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. Sorry, you need to be a researcher to join ResearchGate. Daryl Shorter, M.D., Assistant Professor, is the Director of the Addiction Psychiatry Fellowship program, Associate Program Director of the General Psychiatry Residency program, and the Medical Director for the Outpatient Clinical Trials Research (OCTR) program. (B) Alpha diversity. The primary objective of this study was to determine the safety of lofexidine, an α2 receptor agonist, alone and concurrent with cocaine in non-treatment seeking cocaine-dependent or cocaine-abusing participants.

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